Sykes' lyrics have a strong feeling of catharsis for him.He mainly draws from personal experience and has likened the band's live performances to being therapeutic.In 2017, Sykes featured as guest vocalist in the music video "Silence Speaks" with English metalcore band While She Sleeps.

As an infant, he moved to Australia with his parents, Ian and Carol Sykes, moving between Adelaide and Perth during a period of about six years.

The family returned to the United Kingdom when Sykes was about eight, settling in Stocksbridge in Sheffield, South Yorkshire.

Their latest album, That's the Spirit has been described as various types of rock including alternative rock, electronic rock, emo, and pop punk.

Bring Me the Horizon has been described as metalcore, alternative metal, electronicore, pop punk, pop rock, emo and alternative rock and sometimes heavy metal, post-hardcore and nu metal.

As a teenager, he attended Stocksbridge High School.

He also played in the mock hip-hop band "Womb 2 Da Tomb" with his brother Tom Sykes and fellow Bring Me the Horizon member Matt Nicholls, and in metal band "Purple Curto" with Neil Whiteley, as the drummer/vocalist under the pseudonym "Olisaurus", which he would later use when releasing solo material.In 2004, Sykes formed Bring Me the Horizon, a band which rose to fame very quickly.The band released their debut album Count Your Blessings in 2006.Sykes has also collaborated with DJ Skrillex as the backing vocals of a Bring Me the Horizon song "Visions" off the Bring Me the Horizon album There is a Hell. He performed the song Crawling with producer Zedd on percussion.In addition to his vocal and song writing contributions in Bring Me the Horizon, Sykes is also the founder and owner of the alternative clothing line Drop Dead Clothing. On 1 February 2013, Sykes launched a Kickstarter project to fund a graphic novel created by him and Drop Dead Clothing artist Ben Ashton-Bell, entitled Raised By Raptors.I couldn't understand why I needed a God or, in my opinion, something that doesn't exist." In an interview with in 2013, he also stated "In my opinion, I don't think believing in God is a victimless crime.